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Wnt/β-Catenin—A Canonical Tale of Cell-Fate Choice in the Vertebrate Skeleton

Authors
Journal
Developmental Cell
1534-5807
Publisher
Elsevier
Publication Date
Volume
8
Issue
5
Identifiers
DOI: 10.1016/j.devcel.2005.04.008

Abstract

Three exciting papers in this issue of Developmental Cell provide new insights into the regulation of chondrocytic, osteoblastic, and osteoclastic differentiation during skeletal development and postnatal growth. The studies demonstrate that Wnt/β-catenin signaling represents both a mechanism in mesenchymal precursor cells for selecting between chondrocytic and osteoblastic fates as well as a mechanism in osteoblasts for stimulating the production of an inhibitor of osteoclast formation.

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