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Different Modes of Action of Naphthyridones in Gram-Positive and Gram-Negative Bacteria

Authors
Publisher
American Society for Microbiology
Publication Date
Source
PMC
Keywords
  • Mechanisms Of Action: Physiological Effects

Abstract

Naphthyridones that were recently described as a class of translation inhibitors in gram-positive bacteria mediate their mode of action via GyrA in Haemophilus influenzae and Escherichia coli. These are the first examples of compounds in which modes of action in different bacterial pathogens are mediated through widely different targets.

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