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Interleukin-2 and STAT5 in regulatory T cell development and function

Authors
Journal
JAK-STAT
2162-3988
Publisher
Landes Bioscience
Publication Date
Volume
2
Issue
1
Identifiers
DOI: 10.4161/jkst.23154
Keywords
  • Special Focus Review

Abstract

Interleukin-2 and its downstream target STAT5 have effects on many aspects of immune function. This has been perhaps best documented in regulatory T cells. In this review we summarize the initial findings supporting a role for IL2 and STAT5 in regulatory T cell development and outline more recent studies describing how this critical signaling pathway entrains regulatory T cell differentiation and affects regulatory T cell function.

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