Affordable Access

Leukocyte Adhesion Molecules in Diabetic Retinopathy

Journal of Ophthalmology
Publication Date
  • Biology
  • Medicine


Diabetes is a systemic disease that causes a number of metabolic and physiologic abnormalities. One of the major microvascular complications of diabetes is diabetic retinopathy (DR), a leading cause of blindness in people over age 50. The mechanisms underlying the development of DR are not fully understood; however, extensive studies have recently implicated chronic, low-grade inflammation in the pathophysiology of DR. During inflammation leukocytes undergo sequential adhesive interactions with endothelial cells to migrate into the inflamed tissues, a process known as the “leukocyte recruitment cascade” which is orchestrated by precise adhesion molecule expression on the cell surface of leukocytes and the endothelium. This paper summarizes the recent clinical and preclinical works on the roles of leukocyte adhesion molecules in DR.

There are no comments yet on this publication. Be the first to share your thoughts.


Seen <100 times

More articles like this

Leukocyte Adhesion Molecules in Diabetic Retinopat...

on Journal of Ophthalmology Feb 11, 2011

Adhesion molecules (ICAM-1 and VCAM-1) and diabeti...

on Journal of Molecular Histology April 2008

[Leukocyte adhesion molecules].

on Archives de l'Institut Pasteur... 1992
More articles like this..