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Recent progress in sodium channel modulators for pain

Authors
Journal
Bioorganic & Medicinal Chemistry Letters
0960-894X
Publisher
Elsevier
Publication Date
Identifiers
DOI: 10.1016/j.bmcl.2014.06.038
Keywords
  • Voltage-Gated Sodium Channels
  • Electrophysiology Screening
  • Sodium Channel Toxins
  • Sodium Channel Structure
  • Sodium Channel Drugs
Disciplines
  • Biology
  • Medicine

Abstract

Abstract Voltage-gated sodium channels (Navs) are an important family of transmembrane ion channel proteins and Nav drug discovery is an exciting field. Pharmaceutical investment in Navs for pain therapeutics has expanded exponentially due to genetic data such as SCN10A mutations and an improved ability to establish an effective screen sequence for example IonWorks Barracuda®, Synchropatch® and Qube®. Moreover, emerging clinical data (AZD-3161, XEN402, CNV1014802, PF-05089771, PF-04531083) combined with recent breakthroughs in Nav structural biology pave the way for a future of fruitful prospective Nav drug discovery.

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