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Growth inhibition ofCryptococcus neoformansby 2-(1-piperazinyl)-5-(1,2-diarylethyl)-4,6-dichloropyrimidines: synthesis andin vitrostudies

Authors
Journal
European Journal of Medicinal Chemistry
0223-5234
Publisher
Elsevier
Publication Date
Volume
31
Issue
1
Identifiers
DOI: 10.1016/s0223-5234(96)80010-9
Keywords
  • Pyrimidine Derivative /Cryptococcus Neoformans

Abstract

Abstract 2-(1-Piperazinyl)-5-[1-(4-chlorophenyl)-2-phenylethyl]-4,6-dichloropyrimidine and 2-(1-piperazinyl)-5-[1-(4-chloro-phenyl)-2-(3-chlorophenyl)ethyl]-4,6-dichloropyrimidine were synthesized via organozinc reagents. These new pyrimidine derivatives were tested against human mycoflora. Biological tests showed that these compounds are selective growth inhibitors of Cryptococcus neoformans.

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