Affordable Access

Publisher Website

Substantia nigra self-stimulation: Dependence on noradrenergic reward pathways

Authors
Journal
Behavioral Biology
0091-6773
Publisher
Elsevier
Publication Date
Volume
13
Issue
1
Identifiers
DOI: 10.1016/s0091-6773(75)90853-6
Disciplines
  • Biology
  • Chemistry
  • Pharmacology

Abstract

Electrodes in the dopamine cell groups of the substantia nigra lose their ability to support self-stimulation after mechanical or chemical damage to ipsilateral noradrenergic pathways, or after pharmacological inhibition of norepinephrine synthesis. Replenishment of depleted stores of norepinephrine by central administration of exogenous transmitter selectively reinstates the suppressed behavior. These findings, which demonstrate an essential role for norepinephrine in the mediation of substantia nigra self-stimulation, lend no support to the hypothesis that self-stimulation can result from the activation of dopamine neurons alone.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

[Roles of noradrenergic and dopaminergic systems i...

on Nihon yakurigaku zasshi. Folia... October 1976

Prefrontal cortex lesions attenuate substantia nig...

on Behavioural Brain Research Feb 01, 1989

Prefrontal cortex lesions attenuate substantia nig...

on Behavioural Brain Research Jan 01, 1989
More articles like this..