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MER-25 does not inhibit the activation of aggression by testosterone in adult Rockland—Swiss mice

Authors
Journal
Psychoneuroendocrinology
0306-4530
Publisher
Elsevier
Publication Date
Volume
6
Issue
2
Identifiers
DOI: 10.1016/0306-4530(81)90005-6
Keywords
  • Aggression
  • Mice
  • Mer-25
  • Aromatization

Abstract

Abstract The effect of ethamoxytriphetol (MER-25), an antiestrogen, on testosterone or estrogen induced aggression was evaluated in mice. In accord with previous data, both hormones activated fighting in gonadectomized males and TP induced aggression in ovariectomized females. Concurrent antiestrogen treatment, while significantly suppressing the ability of EB to promote aggression, did not block the capacity of TP to induce fighting in gonadectomized males or females. These data suggest that the aromatization of androgens within the central nervous system may not be essential for the promotion of aggression by testosterone in adult Rockland—Swiss mice.

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