Affordable Access

Publisher Website

In vitro pharmacologic inhibition of rabbit adrenal microsomal cholesterol esterification

Authors
Journal
Pharmacological Research Communications
0031-6989
Publisher
Elsevier
Publication Date
Volume
7
Issue
3
Identifiers
DOI: 10.1016/0031-6989(75)90027-2

Abstract

Abstract Of the seven prostaglandins tested, PGE, and E2 had the greatest in vitro inhibitory effects on incorporation of a palmitoyl CoA substrate into cholesterol esters by rabbit adrenal microsomal fractions. Polyphloretin phosphate (PPP) and a high molecular weight fraction of the parent PPP also had significant inhibitory effects, whereas a low molecular weight fraction and a dimer showed lesser degrees of inhibition. Another polyanionic compound, dextran sulfate, as well as ionic and non-ionic amphipathic compounds (SKF 525-A, sodium taurocholate, sodium decyl sulfate, Tween 20 and Tween 80) also significantly inhibited the adrenal microsomal cholesterol esterification reaction.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

In vitro pharmacologic inhibition of rabbit adrena...

on Pharmacological research commu... June 1975

Cholesterol esterification by rat adrenal gland. I...

on Biochimica et Biophysica Acta Oct 23, 1981

Cholesterol esterification by rat adrenal gland:In...

on Biochimica et Biophysica Acta... Jan 01, 1981
More articles like this..