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Proton NMR studies of the GDP.Mg2+complex of the Ha-ras oncogene product p21

Authors
Publisher
Elsevier Inc.
Publication Date
Volume
150
Issue
1
Identifiers
DOI: 10.1016/0006-291x(88)90540-2

Abstract

Abstract Two-dimensional proton NMR studies were performed on the c-Ha-ras encoded proto-oncogene product p21 C. COSY and NOESY spectra of the p21 C.GDP.Mg 2+ complex show that the ribose H1' proton of the bound GDP is in close proximity to the aromatic side chain of a phenylalanyl residue. From sequence homology with the bacterial elongation factor Tu (EF-Tu) and the known X-ray structure of the EF-Tu.GDP.Mg 2+ complex it may be inferred that the Phe residue in question is either Phe 78 or Phe 82 in the p21 sequence.

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