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In vitro studies of biomedical magnesium alloys in a simulated physiological environment: A review

Authors
Journal
Acta Biomaterialia
1742-7061
Publisher
Elsevier
Volume
7
Issue
4
Identifiers
DOI: 10.1016/j.actbio.2010.12.004
Keywords
  • Biomedical Magnesium Alloy
  • Corrosion And Materials Degradation
  • In Vitro Assessment
  • Simulated Physiological Environment
  • Biomaterials
Disciplines
  • Biology
  • Medicine

Abstract

Abstract In spite of the immense potential of biodegradable magnesium alloys, the fast degradation rates of Mg-based biomedical implants in the physiological environment impose severe limitations in many clinical applications. Consequently, extensive in vitro studies have been carried out to investigate the materials’ performance and fathom the associated mechanisms. Here, an up-to-date review of the in vitro studies on biomedical magnesium alloys in a simulated physiological environment is provided. This review focuses on four topics: (1) materials selection and in vitro biocompatibility of biomedical magnesium alloys; (2) in vitro degradation of biomedical magnesium alloys in simulated physiological environments, specifically discussing corrosion types, degradation rates, corrosion products and impact of the constituents in body fluids on materials degradation; (3) selection of suitable test media for in vitro assessment; and (4) future research trends.

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