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Mycobacterium tuberculosisinfection in patients with cancer, the role of 18-fluorodeoxyglucose positron emission tomography for diagnosis and monitoring treatment response

Authors
Journal
Tuberculosis
1472-9792
Publisher
Elsevier
Publication Date
Volume
87
Issue
5
Identifiers
DOI: 10.1016/j.tube.2007.05.013
Keywords
  • Tuberculosis
  • Treatment
  • Malignancy
  • Positron Emission Tomography
  • Interferon-Gamma
Disciplines
  • Medicine

Abstract

Summary Active tuberculosis (TB) infection including asymptomatic and extrapulmonary disease may be detected with 18-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT). This report highlights the promising role of FDG-PET/CT for evaluation of TB in high-risk, immunocompromised patients with cancer. PET/CT performed for cancer evaluation may detect asymptomatic infection and guide definitive diagnosis. It may also be a useful tool in the assessment of latent TB, to exclude active disease prior to treatment. PET/CT has potential for monitoring response to anti-tuberculosis treatment. Metabolic response may indicate clinical response and guide duration of anti-microbial therapy.

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