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Chronic Eosinophilic Leukemias and the Myeloproliferative Variant of the Hypereosinophilic Syndrome

Authors
Journal
Immunology and Allergy Clinics of North America
0889-8561
Publisher
Elsevier
Publication Date
Volume
27
Issue
3
Identifiers
DOI: 10.1016/j.iac.2007.06.001
Disciplines
  • Medicine

Abstract

Among patients with hypereosinophilia, a myeloproliferative variant is recognized. In many of these patients a diagnosis of eosinophilic leukemia can be made. The molecular mechanism is often a fusion gene, incorporating part of PDGFRA or PDGFRB, encoding anaberrant tyrosine kinase. Prompt diagnosis of such cases is important since specific tyrosine kinase inhibitor therapy is indicated.

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