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Move or Die: the Fate of the Tax Oncoprotein of HTLV-1

Authors
Journal
Viruses
1999-4915
Publisher
MDPI AG
Publication Date
Volume
3
Issue
12
Identifiers
DOI: 10.3390/v3060829
Keywords
  • Review
Disciplines
  • Biology

Abstract

The HTLV-1 Tax protein both activates viral replication and is involved in HTLV-1-mediated transformation of T lymphocytes. The transforming properties of Tax include altering the expression of select cellular genes via activation of cellular pathways and perturbation of both cell cycle control mechanisms and apoptotic signals. The recent discovery that Tax undergoes a hierarchical sequence of posttranslational modifications that control its intracellular localization provides provocative insights into the mechanisms regulating Tax transcriptional and transforming activities.

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