Affordable Access

Publisher Website

Move or die: the fate of the Tax oncoprotein of HTLV-1.

Authors
  • 1
Type
Published Article
Journal
Viruses
1999-4915
Publisher
MDPI AG
Publication Date
Volume
3
Issue
6
Pages
829–857
Identifiers
DOI: 10.3390/v3060829
PMID: 21994756
Source
Medline
Keywords
  • Htlv-1
  • Nf-κB
  • Tax
  • Intracellular Trafficking
  • Leukemia
  • Nuclear Bodies
  • Posttranslational Modifications
  • Retrovirus
  • Signal Transduction

Abstract

The HTLV-1 Tax protein both activates viral replication and is involved in HTLV-1-mediated transformation of T lymphocytes. The transforming properties of Tax include altering the expression of select cellular genes via activation of cellular pathways and perturbation of both cell cycle control mechanisms and apoptotic signals. The recent discovery that Tax undergoes a hierarchical sequence of posttranslational modifications that control its intracellular localization provides provocative insights into the mechanisms regulating Tax transcriptional and transforming activities.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments
F