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Hypothalamic sites of neuronal histamine action on food intake by rats

Authors
Journal
Brain Research
0006-8993
Publisher
Elsevier
Publication Date
Volume
490
Issue
2
Identifiers
DOI: 10.1016/0006-8993(89)90244-8
Keywords
  • Antihistamine
  • H1
  • Histamine H1-Receptor
  • Feeding
  • Ventromedial Nucleus
  • Paraventricular Nucleus
  • Microinfusion
  • α-Fluoromethylhistidine

Abstract

Abstract To identify sites of histaminergic modulation of food intake, histamine H 1-receptor antagonist was microinfused into the rat hypothalamus, the ventromedial hypothalamus (VMH), the lateral hypothalamus (LHA), the paraventricular nucleus (PVN), the dorsomedial hypothalamus (DMH), or the preoptic anterior hypothalamus (POAH), during the early light period. Feeding, but not drinking, was elicited in 100% of the rats ( P<0.01) that were bilaterally microinfused with 26 nmol chlorpheniramine into the VMH. Unilateral infusion into the VMH did not affect food intake at doses of 26 or 52 nmol. Feeding was also induced by bilateral microinfusion into the PVN, but only the 52 nmol dose was effective. Bilateral infusions into the LHA, the DMH or the POAH did not affect ingestive behavior. Feeding induced by an H 1-antagonist was completely abolished in all 7 rats tested when endogenous neuronal histamine was decreased by pretreatment with α-fluoromethylhistidine (100 mg/kg). The findings suggest that H 1-receptors in the VMH and the PVN, but not in the LHA, the DMH or the POAH, may be involved in histaminergic suppression of foof intake.

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