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Prostaglandin H synthase

Authors
Journal
Current Opinion in Structural Biology
0959-440X
Publisher
Elsevier
Publication Date
Volume
4
Issue
4
Identifiers
DOI: 10.1016/s0959-440x(94)90215-1
Keywords
  • Membrane Proteins
Disciplines
  • Biology

Abstract

Abstract The prostaglandin H synthase structure reveals that the enzyme has a fold similar to those of other heme peroxidases, but differing in that a second active site has evolved within this fold which catalyzes the cyclooxygenase reaction. The protein has also acquired two additional domains: a membrane-binding motif that lacks transmembrane segments, mediating attachment to the membrane via helices that lie parallel to the membrane, and an epidermal growth factor-like module found just before the membrane-binding motif. The epidermal growth factor-like module is located in the dimer interface.

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