Affordable Access

Publisher Website

Abnormal T Cell Activation and Skewed T Cell Receptor Vβ Repertoire Usage in Japanese Patients with Idiopathic Portal Hypertension

Authors
Journal
Clinical Immunology and Immunopathology
0090-1229
Publisher
Elsevier - Academic Press
Publication Date
Volume
75
Issue
3
Identifiers
DOI: 10.1006/clin.1995.1073
Disciplines
  • Medicine

Abstract

Abstract Idiopathic portal hypertension (IPH), a disorder of unknown etiology, is characterized by a noncirrhotic portal hypertension associated with splenomegaly, hypersplenism, and anemia. We examined the surface phenotypes of T cells and the T cell receptor Vβ repertoire in patients with IPH. The T cells in peripheral blood samples and from spleens showed a marked increase in frequencies of HLA-DP +- and HLA-DR +-activated T cells and the observed high frequencies in the blood were to a considerable extent reduced after splenectomy. Thus, the continuous activation of T cells may occur initially in the spleen. Investigation of T cell receptor Vβ repertoire revealed a significant skewing of Vβ9 and Vβ11 in both peripheral blood and splenic T cells and Vβ12 in splenic T cells. The IPH may be a disease mediated by a continuous stimulation with either a certain antigen or more likely a superantigen.

There are no comments yet on this publication. Be the first to share your thoughts.