Affordable Access

Publisher Website

Anti-tumor and radiosensitization activities of the iron chelator HDp44mT are mediated by effects on intracellular redox status

Authors
Journal
Cancer Letters
0304-3835
Publisher
Elsevier
Publication Date
Volume
298
Issue
2
Identifiers
DOI: 10.1016/j.canlet.2010.07.010
Keywords
  • Hdp44Mt
  • Redox
  • Radiosensitization
  • Glutathione

Abstract

Abstract A novel iron chelator, HDp44mT, has been reported to have potent anti-proliferative effects on cancer cells; however, the underlying mechanism of action is not well understood. In this study, we characterized the cytotoxic effect of HDp44mT in a chemo- and radio-resistant cell line (PC-3) of prostatic cancer origin. The activity of HDp44mT at nM concentrations was dependent on the intracellular GSH and atmospheric O 2 concentration, rather than iron deprivation. HDp44mT also radiosensitized PC-3 cells in a GSH-dependent manner. Interestingly, this radiosensitizing effect was observed under aerobic and, to a larger extent, hypoxic conditions, suggesting its potential utility as a radiosensitizer for some radioresistant tumors.

There are no comments yet on this publication. Be the first to share your thoughts.