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Anti-inflammatory and peripheral analgesic activity of esculetinin vivo

Authors
Journal
Pharmacological Research Communications
0031-6989
Publisher
Elsevier
Publication Date
Volume
20
Identifiers
DOI: 10.1016/s0031-6989(88)80847-6
Keywords
  • Esculetin
  • Croton Oil
  • Writhing Test
  • Analgesy
  • Inflammation

Abstract

Summary Esculetin determined a reduction in oedema and granulocyte infiltration in the Croton oil ear test in vivo. The drug was able to inhibit Acethylcholine-writhing test and showed a LD50 of 1450 mg/kg i.p. and > 2000 mg/kg by mouth. In our experimental conditions, esculetin has an anti-inflammatory and analgesic effect.

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