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Paradoxical opiate specific paralytic effects of high doses of intracerebroventricular etorphine and fentanyl in rats

Authors
Journal
Pharmacology Biochemistry and Behavior
0091-3057
Publisher
Elsevier
Publication Date
Volume
38
Issue
2
Identifiers
DOI: 10.1016/0091-3057(91)90310-x
Keywords
  • Paralytic Effects
  • Opiate
  • Etorphine
  • Fentanyl

Abstract

Abstract Injections of high doses of etorphine (0.0625, 0.25, or 1.0 μmol) or equimolar fentanyl into the cerebral ventricles of rats induced a sequence of motor effects including catatonia, a novel flaccid paralysis, and recurrent catatonia. These effects were dose related, naloxone reversible, and reveal an opiate specific organization of a central motor hierarchy.

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