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Induction of oxalate binding by dehydroascorbic acid feeding in rat kidney

Authors
Journal
Nutrition Research
0271-5317
Publisher
Elsevier
Publication Date
Volume
13
Issue
6
Identifiers
DOI: 10.1016/s0271-5317(05)80559-7
Keywords
  • Dehydroascorbic Acid
  • Retention Of Oxalate
  • Oxalate Binding
  • Lipid Peroxidation
  • Antioxidants
Disciplines
  • Biology

Abstract

Abstract Feeding dehydroascorbic acid (DHA) to rats produced hyperoxaluria, hypercalcuria and increased retention of oxalate in kidney. Increased oxalate binding in kidney was observed in DHA fed rats and it was found to be associated with increased lipid peroxidation (LPO) reaction and decreased activity of antioxidant enzymes superoxide dismutase (SOD), glutathione peroxidase (GPX), catalase and glutathione-s-transferase (GST) and decreased levels of oxygen free radical scavengers glutathione (GSH) and vitamin E.

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