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Monocyte-mediated suppression of T lymphocyte proliferative response in breast and colorectal cancer patients: Specific action of levamisole on suppressor monocytes

Authors
Journal
International Journal of Immunopharmacology
0192-0561
Publisher
Elsevier
Publication Date
Volume
3
Issue
1
Identifiers
DOI: 10.1016/0192-0561(81)90050-3
Disciplines
  • Biology
  • Design

Abstract

Abstract The present study was designed to specifically investigate the in vitro effect of levamisole on responding T lymphocytes and/or suppressor monocytes in patients with breast and colorectal cancer. The mean T lymphocyte response to PHA in the presence of irradiated autologous monocytes was significantly depressed as compared to that in the presence of irradiated autologous T cells in 22 patients with breast cancer ( P<0.001) or in 28 patients with colorectal cancer ( P<0.005). The in vitro treatment of responding T lymphocytes with levamisole failed to enhance the T lymphocyte response to phytohemmagglutinin. The treatment of irradiated monocytes with levamisole (1, 10 or 100 μg/ml), on the other hand, variably lessened the suppressor activity in patients with breast and colorectal cancer. The mean PHA response of T lymphocytes in the presence of levamisole-treated monocytes was significantly higher than that in the presence of saline-treated monocytes in these patients ( P<0.025). Reversal effect of levamisole at a low dose level (1 μg/ml) was not significantly different from that at high dose levels (10 or 100 μg/ml). Our data indicate that the enhancement of T lymphocyte response to PHA is secondary to the specific action of levamisole on suppressor monocytes in breast cancer or colorectal cancer patients.

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