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The effect of substitution patterns on the release rates of opioid peptides DADLE and [Leu5]-enkephalin from coumarin prodrug moieties

Authors
Journal
Bioorganic Chemistry
0045-2068
Publisher
Elsevier
Publication Date
Volume
32
Issue
2
Identifiers
DOI: 10.1016/j.bioorg.2003.12.002
Keywords
  • Coumarin
  • Cyclic Prodrug
  • Opioid Peptide
  • Esterase
  • Structural Effect

Abstract

Abstract A coumarin-based prodrug system has been developed in our laboratory for the preparation of esterase-sensitive prodrugs of amines, peptides, and peptidomimetics. The drug release rates from this prodrug system were found to be dependent on the structural features of the drug moiety. The effect of the phenyl ring substitutions on the release kinetics of such prodrugs of model amines was examined recently and it was found that appropriately positioned alkyl substituents on the phenyl ring could help to facilitate the release. Aimed at further understanding the structure–release rate relationship of the coumarin-based cyclic prodrugs, we synthesized and examined a series of substituted coumarinic acid derivatives of opioid peptides, DADLE, and [Leu 5]-enkephalin.

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