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Routine identification and determination of 11 barbiturates in biological samples

Authors
Publisher
Elsevier B.V.
Publication Date
Volume
93
Issue
3
Identifiers
DOI: 10.1016/0009-8981(79)90290-0
Disciplines
  • Biology
  • Medicine
  • Pharmacology

Abstract

Abstract A very easy, reliable and specific gas-chromatographic method for identification and dosage of 11 barbiturates in plasma is presented. Méthylene unit values determined on two types of column (one polar, one non-polar) allows very accurate identification with a minimum risk of error due to fluctuations in operating conditions. Sensitivity of the method is 0.5 μg/ml plasma with a flame ionization detector. Derivatization procedure is complete, without any degradation phenomenon as tested by mass spectrometry. Such a method can be easily used as routine procedure for toxicological or pharmacological applications.

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