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Repatterning in amphibian limb regeneration: A model for study of genetic and epigenetic control of organ regeneration

Authors
Journal
Seminars in Cell and Developmental Biology
1084-9521
Publisher
Elsevier
Publication Date
Volume
20
Issue
5
Identifiers
DOI: 10.1016/j.semcdb.2008.12.007
Keywords
  • Axial Pattern Formation
  • Positional Information
  • Epigenetic Regulation
  • Organ Regeneration
Disciplines
  • Biology

Abstract

Abstract Limb regeneration is an excellent model for understanding organ reconstruction along PD, AP and DV axes. Re-expression of genes involved in axial pattern formation is essential for complete limb regeneration. The cellular positional information in the limb blastema has been thought to be a key factor for appropriate gene re-expression. Recently, it has been suggested that epigenetic mechanisms have an essential role in development and regeneration processes. In this review, we discuss how epigenetic mechanisms may be involved in the maintenance of positional information and the regulation of gene re-expression during limb regeneration.

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