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Catch and the mechanism of action of 5-hydroxytryptamine on molluscan muscle: A speculation

Authors
Journal
Life Sciences
0024-3205
Publisher
Elsevier
Publication Date
Volume
5
Issue
13
Identifiers
DOI: 10.1016/0024-3205(66)90042-7

Abstract

Abstract It is speculated that catch in molluscan muscle depends on sustained high levels of free intracellular calcium ion, that 5-HT (5-hydroxytryptamine, serotonin) in proportion to its concentration, increases the binding of intracellular calcium to a “relaxing” system, and that reduction of intracellular free calcium explains the apparent paradox that catch is relaxed while membrane excitability is increased. The speculations are based upon experiments detailing the relationship between 5-HT concentration and its action on catch and membrane excitability. An analogy is made between these results and the relationship between calcium concentration and action on contractility and membrane excitability in a striated muscle.

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