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Biological properties of the C-8 substituted analogues of 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA)

Publication Date
  • Anps
  • Immunostimulatory
  • Acyclic Nucleoside Phosphonates
  • Pmea


The 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA) derivatives substituted at the C-8 position of the purine moiety did not exhibited any pronounced antiviral or antimalarial activity, but both 8-hydroxy and 8-sulfanyl derivatives of PMEA possess significant immunostimulatory activities.

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