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S-adenosylhomocysteine is a more sensitive indicator of renal insufficiency than homocysteine

Authors
Journal
Nutrition Research
0271-5317
Publisher
Elsevier
Publication Date
Volume
24
Issue
7
Identifiers
DOI: 10.1016/j.nutres.2004.04.005
Keywords
  • Homocysteine
  • S-Adenosylhomocysteine
  • Renal Insufficiency
  • Vascular Disease
Disciplines
  • Medicine

Abstract

Abstract Patients with decreased renal function have a very high incidence of cardiac disease and stroke and have very high levels of plasma homocysteine. We have shown that plasma S-adenosylhomocysteine is a more sensitive indicator of the risk for cardiovascular disease than is plasma homocysteine. We measured plasma S-adenosylhomocysteine and total homocysteine in 36 patients with renal insufficiency and in 17 control subjects. The mean (± SD) value of S-adenosylhomocysteine for renal patients was 90.4 ± 49.4 nmol/L, and the corresponding value for control subjects was 25.8 ± 6.0 nmol/L. The mean value of homocysteine for renal patients was 20.9 ± 7.2 μmol/L, and the corresponding value for control subjects was 10.9 ± 2.7 μmol/L. For S-adenosylhomocysteine, the values of four patients overlapped those of control subjects, whereas for homocysteine 10 patient values overlapped control values. S-adenosylhomocysteine is a more sensitive indicator than homocysteine for renal disease (89% v 72%, respectively, P = 0.034).

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