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1H-NMR studies of the interactions of two distamycin analogues with the dodecamer d(CGCGAATTCGCG)2.

Authors
Journal
Bioorganic & Medicinal Chemistry Letters
0960-894X
Publisher
Elsevier
Publication Date
Volume
2
Issue
10
Identifiers
DOI: 10.1016/s0960-894x(00)80234-6

Abstract

Abstract High resolution proton NMR techniques have been used to study the interaction between the self complementary Dickerson dodecamer d(CGCGAATTCGCG) 2 and two distamycin analogues containing a retroinverted amide bond. The results indicated that both analogues, although binding the Dickerson dodecamer less strongly than distamycin, span the central AATT segment in the minor groove in a similar fashion.

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