Affordable Access

Publisher Website

A mild and efficient route to the pharmacophore of the enediyne antitumor agents - (Z)-1,6-[bis (trimethylsilyl)-hex-3-ene-1,5-diyneviaa novel carbenoid coupling reaction

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
35
Issue
17
Identifiers
DOI: 10.1016/s0040-4039(00)76998-x

Abstract

Abstract (Z)-1,6-[Bis (trimethylsilyl)]-hex-3-ene-1,5-diyne has been prepared in high yield and in one pot from trimethylsilylpropargyl bromide by a remarkably stereoselective tandem carbenoid coupling-HX elimination sequence.

There are no comments yet on this publication. Be the first to share your thoughts.