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[3H]Kainic acid binding and choline acetyltransferase activity in alzheimer's dementia

Authors
Journal
Brain Research
0006-8993
Publisher
Elsevier
Publication Date
Volume
310
Issue
2
Identifiers
DOI: 10.1016/0006-8993(84)90164-1
Keywords
  • [3H]Kainic Acid Binding
  • Choline Acetyltransferase Activity
  • Caudate Nucleus
  • Alzheimer'S Dementia

Abstract

Abstract The binding of [ 3H]kainic acid to caudate nucleus membranes prepared from brains of examples of Alzheimer's dimentia and controls has been determined. No changes were detected in either the affinity of the number of kainate binding sites in the Alzheimer samples compared to control, although there was a large decrease in choline acetyltransderase activity.

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