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Moderate consumption of marine n-3 fatty acids is associated with a lower risk of atrial fibrillation – a Danish cohort study

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  • Medicine

Abstract

Moderate consumption of marine n-3 fatty acids is associated with a lower risk of atrial fibrillation – a Danish cohort study Thomas Andersen Rix1, MD; Albert Marni Joensen1, MD, PhD; Sam Riahi1,2, MD, PhD; Søren Lundbye-Christensen1, MSc, PhD; Anne Tjønneland3, MD, PhD, DMSc; Erik Berg Schmidt1, MD, DMSc; Kim Overvad1,4 MD, PhD 1Department of Cardiology, Aalborg AF Study Group, Center for Cardiovascular Research, Aalborg University Hospital, Denmark 2Department of Health Science and Technology, Faculty of Medicine, Aalborg University 3Danish Cancer Society Research Center, Copenhagen, Denmark 4Section for Epidemiology, Department of Public Health, Aarhus University, Denmark Purpose Some studies have reported a beneficial effect of fish intake with respect to development of atrial fibril- lation (AF), but results have been inconsistent. The aim of this study was to examine the hypothesis of a negative association between consumption of marine n-3 polyunsaturated fatty acids (PUFA) and the de- velopment of AF. Methods A total of 57,053 Danish participants 50 to 64 years of age were enrolled into the Diet, Cancer, and Health Cohort Study between 1993 and 1997. Baseline data included information on health, medication, lifestyle, and a semi-quantitative food frequency questionnaire including 20 questions regarding intake of fish and food products containing fish, as well as measure- ments of anthropometry, blood pressure, and blood samples. Follow-up was done using the National Pa- tient Registry, which records diagnoses from in-pa- tient and out-patient hospital visits in Denmark. The validity of the diagnosis AF was high with a positive predictive value of 92.6 %. Data was analysed in a pre-specified, sex-stratified, multivariate Cox regres- sion model with age as the time axis and modelling risk according to a restricted cubic spline of n-3 PUFA consumption, which allows modelling non-linear as- sociations. As a supplement, quintiles of n-3 PUFA consumption were exp

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