Affordable Access

Publisher Website

Nitrosation of the antimicrobial drug hexetidine: Nitrosamines derived from a triamine decomposition product

Authors
Journal
Food and Chemical Toxicology
0278-6915
Publisher
Elsevier
Publication Date
Volume
31
Issue
1
Identifiers
DOI: 10.1016/0278-6915(93)90179-3

Abstract

Abstract Five new nitrosamines were identified as nitrosation products of N 1, N 3-bis(2-ethylhexyl)-2-methyl-1,2,3-propantriamine, a hydrolysis product usually found in preparations of the antimicrobial drug hexetidine. All nitrosamines are formed after deamination of the primary amino group by nitrosation of one of the two secondary amino groups. The propantriamine derivative is very easily nitrosatable, with total nitrosamine yields in the upper range of a comparative scale of drug nitrosatability.

There are no comments yet on this publication. Be the first to share your thoughts.