Affordable Access

Publisher Website

A facile access to natural and unnatural dialkylsubstituted maleic anhydrides

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
43
Issue
37
Identifiers
DOI: 10.1016/s0040-4039(02)01469-7

Abstract

Abstract A facile new route to naturally occurring 2-carboxyethyl-3-octylmaleic anhydride ( 1a ) and unnatural dioctylmaleic anhydride ( 11 ) has been demonstrated via a chemoselective S N2′ Grignard coupling reaction with dimethyl bromomethylfumarate ( 3 ) followed by a chemoselective diethyl malonate/Grignard coupling reaction pathway.

There are no comments yet on this publication. Be the first to share your thoughts.