It has been possible to isolate the spiro chaeta micro organism to the birds from infected tick and poultry in different regions across the republic (EL-Kanater, Banha, Cairo, EL-Wady EL-Gedeed and Wady EL-Natron), it has been also isolated 2 strain from duck and turkeys. (Banha EL-Wady EL-Gedeed) by performing the precipitating agar test, challenge , and passage from bird to birds. It revealed it same disease in different bird (dhickens, turkeys and duck). It is source as on strain of the Borrelia anserina strain for Birds present in Egypt. It has been possible to maintain the micro organisms at different of temperature from (37oC to- 70oC) the virulence of strain over the different kinds chickens breed in Egypt the most resistance and endurance the disease are Fayoumy poultry where the more effect are isa babcock type. By comparing the usage of the various anti biotic in drinking water flumeqiun 10%the sulphaguanidi AS, for deep g/m the use of pencillin procain to pencillin K. Sodium give in one dose. Is sufficin to demolish the Borrelia amserima from the infected bird, while the use of pencillin G. Sodium alone required to 5 days consecutive the increase Y. of formalin did not affect the aquired immunity whereby a deficiency lead to rednction in the period of aquried immunity. Concernin the lyophilized vaccine in one ml I/M give level of immunity stable for more than 24 weeks.