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Apparent lack of correlation between the loss of cytochrome P-450 in hepatic parenchymal cell culture and the stimulation of haem oxygenase activity

Authors
Journal
Biochemical and Biophysical Research Communications
0006-291X
Publisher
Elsevier
Publication Date
Volume
81
Issue
2
Identifiers
DOI: 10.1016/0006-291x(78)91589-9
Disciplines
  • Biology

Abstract

Abstract The hypothesis that the stimulation of haem oxygenase activity in cultured adult rat liver parenchymal cells is intimately associated with the accelerated breakdown of the haemoprotein cytochrome P-450 was examined. Even though the time course of the loss of cytochrome P-450 and the stimulation of haem oxygenase activity were found to be compatible with this hypothesis, further work however showed that high levels of cytochrome P-450 could be maintained in liver cell culture in the face of high haem oxygenase activities.

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