Affordable Access

Access to the full text

A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation

Authors
  • Voet, Sofie1, 2
  • Mc Guire, Conor1, 2, 3, 4
  • Hagemeyer, Nora5
  • Martens, Arne1, 2
  • Schroeder, Anna6, 7
  • Wieghofer, Peter5, 8
  • Daems, Carmen9
  • Staszewski, Ori5
  • Vande Walle, Lieselotte1, 10
  • Jordao, Marta Joana Costa5
  • Sze, Mozes1, 2
  • Vikkula, Hanna-Kaisa1, 2
  • Demeestere, Delphine1, 2
  • Van Imschoot, Griet1, 2
  • Scott, Charlotte L.1, 2
  • Hoste, Esther1, 2
  • Gonçalves, Amanda1, 2, 11
  • Guilliams, Martin1, 2
  • Lippens, Saskia1, 2, 11
  • Libert, Claude1, 2
  • And 9 more
  • 1 VIB Center for Inflammation Research, Ghent, B-9052, Belgium , Ghent (Belgium)
  • 2 Ghent University, Department of Biomedical Molecular Biology, Ghent, B-9052, Belgium , Ghent (Belgium)
  • 3 VIB Center for Medical Biotechnology, Ghent, B-9052, Belgium , Ghent (Belgium)
  • 4 Ghent University, Department of Biochemistry and Microbiology, Ghent, B-9052, Belgium , Ghent (Belgium)
  • 5 University of Freiburg, Institute of Neuropathology, Faculty of Medicine, Freiburg, D-79106, Germany , Freiburg (Germany)
  • 6 VIB Center for Brain & Disease Research, Leuven, B-3000, Belgium , Leuven (Belgium)
  • 7 KU Leuven, Department of Neurosciences, Leuven, B-3000, Belgium , Leuven (Belgium)
  • 8 University of Leipzig, Institute of Anatomy, Leipzig, D-04103, Germany , Leipzig (Germany)
  • 9 KU Leuven, Department of Human Genetics, Leuven, B-3000, Belgium , Leuven (Belgium)
  • 10 Ghent University, Department of Internal Medicine, Ghent, B-9052, Belgium , Ghent (Belgium)
  • 11 VIB Bio-Imaging Core, Ghent, B-9052, Belgium , Ghent (Belgium)
  • 12 Weizmann Institute of Science, Department of Immunology, Rehovot, I-76100, Israel , Rehovot (Israel)
  • 13 Washington University of Medicine, Department of Pathology and Immunology, St. Louis, MO, 63110, USA , St. Louis (United States)
  • 14 KU Leuven, Laboratory of Biological Psychology, Leuven, B-3000, Belgium , Leuven (Belgium)
  • 15 University of Freiburg, BIOSS Centre for Biological Signalling Studies, Freiburg, D79106, Germany , Freiburg (Germany)
Type
Published Article
Journal
Nature Communications
Publisher
Springer Nature
Publication Date
May 23, 2018
Volume
9
Issue
1
Identifiers
DOI: 10.1038/s41467-018-04376-5
Source
Springer Nature
License
Green

Abstract

As resident macrophages of the brain, microglia are important for neuroinflammatory responses. This work shows that nuclear factor kappa B regulatory protein A20 is important for microglia activation and regulation during inflammation of the central nervous system.

Report this publication

Statistics

Seen <100 times