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Fluorescent patterns of antibodies to mitochondria, endoplasmic reticulum and ribosomes

Authors
Journal
Acta Histochemica
0065-1281
Publisher
Elsevier
Publication Date
Volume
71
Issue
1
Identifiers
DOI: 10.1016/s0065-1281(82)80014-7
Disciplines
  • Biology
  • Medicine

Abstract

Summary The fluorescent patterns of autoantibodies to mitochondria, endoplasmic reticulum and ribosomes are described. Mitochondrial autoantibodies can be now divided in 10 types, microsomal antibodies at least in 3 types. Using rat renal tissue sections the typical fluorescent pattern of new antimitochondrial antibodies were: type 7, distal tubulus and third portion of proximal tubules, type 8 distal tubules, only, type 9 first and second portion of proximal tubules, type 10 strong reaction of distal and third portion of proximal tubules. The new pattern of ribosomal antibody is characterized by a cytoplasmic staining of rat hepatocytes especially in the central area of the liver lobule. The heterogeneity of cytoplasmic autoantibodies can be used as a diagnostic marker in different pathological conditions, if the different staining patterns is taken into account.

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