Affordable Access

Publisher Website

Two-year feeding and multigeneration studies in rats on five chemically modified starches

Food and Cosmetics Toxicology
Publication Date
DOI: 10.1016/0015-6264(74)90236-3
  • Chemistry
  • Medicine
  • Pharmacology


Abstract Five chemically modified starches, acetylated distarch phosphate, acetylated diamylopectin phosphate, starch acetate, hydroxypropyl distarch glycerol and phosphated distarch phosphate, were fed to rats at dietary levels of 0 (control), 5, 10 and 30% for 2 yr and at one level, 10%, over three generations. In the 2-yr study, no adverse effects were observed on mortality, food intake, haematology, blood biochemistry or urine composition. Each of the modified starches examined, except the phosphated distarch phosphate, slightly reduced body weights at the 30% level and caused distinct caecal enlargement at 10 and 30%, but the microscopic structure of the caecal wall was normal. In comparison with the controls, the males fed the 30% level of any of the modified starches showed a slightly increased degree and incidence of focal hyperplasia of the renal papillary and pelvic epithelium, accompanied by calcified patches in the underlying tissue. The studies did not provide any indication of carcinogenicity. The multigeneration study showed no effect on fertility, on lactation performance or on embryonic or pre-weaning mortality. Extensive microscopic examination of the F 3b-generation rats failed to reveal any changes attributable to treatment. It was concluded that the feeding of each of the modified starches at dietary levels up to 30% for 2 yr and at a level of 10% over three generations did not result in any distinct effect of toxicological significance.

There are no comments yet on this publication. Be the first to share your thoughts.


Seen <100 times

More articles like this

Two-year feeding amd multigeneration studies in ra...

on Food and cosmetics toxicology October 1974

Two-year oral toxicity and multigeneration studies...

on Food and cosmetics toxicology February 1979

Two-year oral toxicity and multigeneration studies...

on Food and Cosmetics Toxicology Jan 01, 1979

Safety evaluation of yeast grown on hydrocarbons....

on Food and cosmetics toxicology December 1971
More articles like this..