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Identification of a dual histamine H1/H3receptor ligand based on the H1antagonist chlorpheniramine

Authors
Journal
Bioorganic & Medicinal Chemistry Letters
0960-894X
Publisher
Elsevier
Publication Date
Volume
13
Issue
12
Identifiers
DOI: 10.1016/s0960-894x(03)00357-3

Abstract

Abstract Combining the first generation H 1 antihistamine chlorpheniramine ( 1) with H 3 ligands of the alkylamine type has led to the identification of compound 9d, a dual ligand of both the H 1 and H 3 receptors.

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