Affordable Access

Publisher Website

Diamminetetrakis(carboxylato)platinum(IV) Complexes – Synthesis, Characterization, and Cytotoxicity

Authors
Journal
Chemistry & Biodiversity
1612-1872
Publisher
Wiley Blackwell (John Wiley & Sons)
Publication Date
Volume
9
Issue
9
Identifiers
DOI: 10.1002/cbdv.201200019
Keywords
  • Medicinal Bioinorganic Chemistry

Abstract

Abstract A series of eight novel diamminetetrakis(carboxylato)platinum(IV) complexes was synthesized and characterized by multinuclear 1H-, 13C-, 15N-, and 195Pt-NMR spectroscopy. Their antiproliferative potency was evaluated in three human cancer cell lines representing ovarian (CH1), lung (A549), and colon carcinoma (SW480). In cisplatin-sensitive CH1 cancer cells, cytotoxicity was found in the low micromolar range, whereas, in inherently cisplatin-resistant A549 and SW480 cells, the activity was very low or negligible. Astonishingly, raise in lipophilicity of the complexes, as found in the case of cisplatin analogs, did not result in a significant enhancement of the cytotoxic effect.

There are no comments yet on this publication. Be the first to share your thoughts.