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Kynurenines and other novel therapeutic strategies in the treatment of dementia

Authors
Journal
Therapeutic Advances in Neurological Disorders
1756-2856
Publisher
SAGE Publications
Publication Date
Volume
6
Issue
6
Identifiers
DOI: 10.1177/1756285613494989
Disciplines
  • Biology
  • Medicine
  • Psychology

Abstract

Microsoft Word - Kynurenines and other novel therapeutic strategies in the treatment of dementia-revised2.docx 1 Kynurenines and other novel therapeutic strategies in the treatment of dementia Zsófia Majláth1, János Tajti1, László Vécsei* 1, 2 1 University of Szeged, Department of Neurology, Semmelweis u. 6, H-6725, Szeged Hungary 2 Neurology Research Group of the Hungarian Academy of Sciences and University of Szeged, Semmelweis u. 6, H-6725 Szeged, Hungary *Corresponding author. E-mail: [email protected], Tel.: +36-62-545348, Fax: +36-62- 545597 2 Abstract: Dementia is a common neuropsychological disorder with an increasing incidence. The most prevalent of the different types of dementia is Alzheimer’s disease. The underlying pathophysiological features of the cognitive decline are neurodegenerative processes, a cerebrovascular dysfunction and immunological alterations. The therapeutic approaches are still limited, although intensive research is being conducted with the aim of finding neuroprotective strategies. The widely accepted cholinesterase inhibitors and glutamate antagonists did not meet the expectations that they would prevent disease progression, and the research is therefore currently focusing on novel targets. Nonsteroidal anti-inflammatory drugs, secretase inhibitors and statins are promising drug candidates for the prevention and management of different forms of dementia. The kynurenine pathway has been associated with various neurodegenerative disorders and cerebrovascular diseases, it is closely related to neuroinflammatory processes too, and it has been implicated in the pathomechanisms of certain kinds of dementia. Targeting the kynurenine system may be of therapeutic value in the future. Keywords: dementia, Alzheimer’s disease, kynurenine, neuroprotective agents 1. Introduction Dementia is an acquired cognitive decline, beyond what might be attributed to normal agi

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