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Inotropic effects of activation and pharmacological mechanisms in cardiac muscle

Authors
Journal
Trends in Pharmacological Sciences
0165-6147
Publisher
Elsevier
Publication Date
Volume
2
Identifiers
DOI: 10.1016/0165-6147(81)90348-5
Disciplines
  • Biology

Abstract

Abstract ‘Staircase’ phenomena in heart muscle simply reflect changes of the amount of calcium at its release sites according to textbook explanations. Available evidence, however, implicates intracellular sodium and the sodium pump as well as cyclic AMP and enzymes involved in regulatory protein phosphorylation in potentiation phenomena. A better understanding of these mechanisms can be an important aid in the investigation of cardioactive drugs and possibly will be relevant in related areas of research, such as electro-secretory coupling and neurophysiology.

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