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In Vitro and In Vivo Activities of Tea Catechins against Helicobacter pylori

Authors
Publisher
American Society for Microbiology
Publication Date
Source
PMC
Keywords
  • Susceptibility
Disciplines
  • Medicine

Abstract

The catechin epigallocatechin gallate showed the strongest activity of the six tea catechins tested against Helicobacter pylori (MIC for 50% of the strains tested, 8 μg/ml). It had bactericidal activity at pH 7 but not at pH ≤5.0. In infected Mongolian gerbils, H. pylori was eradicated in 10 to 36% of the catechin-treated animals, with significant decreases in mucosal hemorrhage and erosion. Tea catechins, therefore, may have therapeutic effects on H. pylori infection.

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