Affordable Access

Publisher Website

Cortical inhibition in alexithymic patients with borderline personality disorder

Authors
Journal
Biological Psychology
0301-0511
Publisher
Elsevier
Publication Date
Volume
88
Identifiers
DOI: 10.1016/j.biopsycho.2011.08.006
Keywords
  • Transcranial Magnetic Stimulation
  • Cortical Silent Period
  • Transcallosal Conduction Time
  • Borderline Personality Disorder
  • Alexithymia
Disciplines
  • Medicine

Abstract

Abstract High levels of alexithymia, a personality trait closely associated with emotion dysregulation, have been found in several psychiatric disorders including borderline personality disorder (BPD). Both BPD and alexithymia have been related to impaired cortical inhibition; however, this relationship has not been tested directly. The aim of the present study was, therefore, to investigate whether cortical inhibition is modulated by alexithymia in BPD. Fifteen BPD patients with Toronto-Alexithymia Scale (TAS-20) scores ≥61, 14 BPD patients with TAS-20 <61, and 16 healthy controls were examined using different TMS paradigms. High-alexithymia patients showed a shortened cortical silent period (CSP) compared to low-alexithymia patients and controls. Additionally, a significant inverse correlation was found between the TAS-20, the left CSP and the left transcallosal conduction time. These findings indicate that alexithymia is associated with changes in GABAergic neurotransmission and facilitated transcallosal inhibition. The results highlight the importance of considering alexithymia in BPD.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Alexithymic traits and facial emotion recognition...

on Psychotherapy and psychosomati... 2011

The wish to be held: female patients with borderli...

on Psychiatry and clinical neuros... October 1996

Genetics of patients with borderline personality d...

on The Psychiatric clinics of Nor... March 2000
More articles like this..