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Eight new cytotoxic metabolites closely related to onnamide A from two marine sponges of the genusTheonella

Authors
Journal
Tetrahedron
0040-4020
Publisher
Elsevier
Publication Date
Volume
48
Issue
39
Identifiers
DOI: 10.1016/s0040-4020(01)86585-6

Abstract

Abstract New cytotoxic compounds 1– 7 were isolated along with onnamide A ( 9) from a marine sponge Theonella sp. collected at Hachijo Island, whereas another Theonella sponge yielded 8. The structures of these compounds were determined by interpretation of the NMR spectral data as well as by comparison of spectral data with those of 9. Six compounds ( 1– 6) were highly cytotoxic against the P388 cell line.

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