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The G to A polymorphism at -597 of the interleukin-6 gene is extremely rare in southern Han Chinese

Authors
Publisher
Elsevier Ltd
Publication Date
Volume
55
Issue
1
Identifiers
DOI: 10.1016/j.cyto.2011.03.006
Keywords
  • Interleukin-6
  • Genetic Polymorphism
  • Chinese
Disciplines
  • Biology
  • Medicine

Abstract

Abstract Interleukin-6 (IL-6) is a cytokine involved in different physiologic and pathophysiologic processes including essential hypertension (EH). Associations of the IL-6 promoter region polymorphisms with circulating level of IL-6 have been reported in various studies. We detected the IL-6-597G/A polymorphism in 246 EH patients and 194 healthy controls from Jiangsu area (south of China). Individuals all carried the GG wild genotype, no GA or AA genotypes were found. Our results suggest that IL-6-597G/A polymorphism is extremely rare and unlikely to be contributing significantly to disease susceptibility in southern Han Chinese.

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