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A growth factor for hepatocytes is inactivated by sub-lethal γ-irradiation in vivo or in vitro

Authors
Publisher
Elsevier B.V.
Publication Date
Volume
245
Identifiers
DOI: 10.1016/0014-5793(89)80211-x
Keywords
  • Liver Growth Factor
  • Prostaglandin E2
  • Liver Regeneration
  • Ionizing Irradiation

Abstract

Abstract Serum from partially hepatectomised rats promoted DNA synthesis in primary adult rat hepatocyte cultures. If the rats had been exposed to sub-lethal γ-irradiation immediately following operation or if their serum, collected at 3 h, was exposed to irradiation in vitro, the growth-promoting activity was destroyed. Prostaglandin E 2 also stimulated DNA synthesis in the cultures; if PGE 2 was irradiated in serum from intact or partially hepatectomised rats its growth-promoting activity was markedly diminished.

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