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Hydropathy analysis to correlate structure and function of proteins

Authors
Journal
Biochemical and Biophysical Research Communications
0006-291X
Publisher
Elsevier
Publication Date
Volume
323
Issue
3
Identifiers
DOI: 10.1016/j.bbrc.2004.08.186
Keywords
  • Hydropathy Index
  • Structure And Function
  • Functional Assignment
  • 3D Hydropathy Patterning
  • Hydropathy Pattern Database
Disciplines
  • Biology

Abstract

Abstract In post-genomic era, a plethora of protein structures have been solved but the functions of some of them are unknown. In this context, the role of hydropathy index of amino acids in predicting the function of a structurally known and functionally unknown protein was explored. Initially serine protease class was taken for analysis. Various methodologies like calculation of average hydropathy index for a five-residue window of a given sequence, hydropathy cluster analyses, etc., were done. Among these, the distribution of hydropathy clusters seems to suggest that the location of these clusters is conserved for a given class of proteins. Hence, this methodology was extended to different classes of proteins and to a protein with unknown function.

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