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1,2,4-Triazolines

Authors
Publisher
Elsevier Science & Technology
Identifiers
DOI: 10.1016/s0065-2725(08)60799-0
Disciplines
  • Chemistry

Abstract

Publisher Summary The formation of a 1,2, 4-triazoline heterocycle was first observed by Pinner, in the course of his classic work on the synthesis of amidrazones by the reaction of an imidate with hydrazine; 15 years later, an example was synthesized by Busch and Ruppenthal by the cyclocondensation of an amidrazone with an aldehyde. Since then, the birth of the concept of 1,3-dipolar cycloadditions along with the discovery of several new classes of 1,3-dipoles from the laboratories of Huisgen and associates has contributed greatly to the development of 1,2,4-triazoline chemistry. This chapter surveys the synthesis, physical properties, and chemical reactions of 1,2,4-triazolines and covers the literature through 1986 to the middle of 1987. Triazolines bearing ring-linked functions that are potentially aromatic, such as 4, =S, =N-R, and =CRR are not considered.

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